Istradefylline 40 mg/working day increased peak amounts and AUC of CYP3A4 substrates in clinical trials. This effect was not noticed with istradefylline 20 mg/day. Take into account dose reduction of sensitive CYP3A4 substrates. darifenacin will boost the amount or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. https://charlesn158ycg6.develop-blog.com/profile