Pentobarbital will decrease the level or result of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. pentobarbital will reduce the level or effect of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Powerful CYP3A4 inducers may minimize suvorexant efficacy; if amplified suvorexant dose demanded, will ... https://henrya185prs3.corpfinwiki.com/user