Interactions with Benzodiazepines and Other CNS Depressants Inform patients and caregivers that potentially fatal additive effects may well manifest if acetaminophen and codeine phosphate tablets are used with benzodiazepines or other CNS depressants, which includes alcohol, rather than to employ these drugs concomitantly Until supervised by a healthcare provider (see https://directoryorg.com/listings13188625/not-known-facts-about-codeine-toux