In the LSD-bound crystal construction, the aspect chain in the lid residue L209EL2 sorts comprehensive hydrophobic contacts with each LSD and surrounding residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to expose the binding pocket in simulation, many of such contacts broke. We Therefore https://lsdcrystal57537.imblogs.net/84727137/lsd-crystal-for-dummies