There's a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to reduce afferent ache transmission and deliver analgesia. Thus, drugs like clonidine that concentrate on alpha-two receptors can impact the transmission of ache. This doc will not comprise all https://www.proleviate.com/post/the-new-pain-killer-conolidine